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KMID : 0606920170250010004
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Biomolecules & Therapeutics
2017 Volume.25 No. 1 p.4 ~ p.11
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Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein Activation
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Duc Nguyen Minh
Kim Hee-Ryung
Chung Ka-Young
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Abstract
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Heterotrimeric G proteins are key intracellular coordinators that receive signals from cells through activation of cognate G protein-coupled receptors (GPCRs). The details of their atomic interactions and structural mechanisms have been described by many biochemical and biophysical studies. Specifically, a framework for understanding conformational changes in the receptor upon ligand binding and associated G protein activation was provided by description of the crystal structure of the β2-adrenoceptor-Gs complex in 2011. This review focused on recent findings in the conformational dynamics of G proteins and GPCRs during activation processes.
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KEYWORD
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G protein, G protein-coupled receptor, Structure, Dynamics
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